Antioxidant role of fruit extract of Emblica officanialis (amla) against arsenic induced renal-toxicity in mice.

Manish Kumar Singh; Devendra Kumar Katiyar; Suraj Singh Yadav; Vineeta Gupta; Sanjay Khattri

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Original Research
Online Published: 02 Nov 2013

AAM. 2013; 2(3): 61-71

Antioxidant role of fruit extract of Emblica officanialis (amla) against arsenic induced renal-toxicity in mice.

Manish Kumar Singh, Devendra Kumar Katiyar, Suraj Singh Yadav, Vineeta Gupta, Sanjay Khattri.

Abstract
The sub-chronic exposure of arsenic is associated with human health risk including renal-toxicity, hepatic-toxicity and neuro-toxicity. The protective efficacy of fruit extract of Emblica-officinalis (amla) was studied in Balb/c mice against arsenic induced renal toxicity.
The study was divided in four groups having five mice in each group. Increased arsenic level in renal tissue associated with enhanced oxidative stress, decrease in the levels of glutathione and activity of superoxide dismutase, catalase and glutathione peroxidase was observed in mice exposed to arsenic (sodium arsenite, 3 mg/kg body weight, p.o., 30 days).
Simultaneous treatment of amla (500 mg/kg body weight, p.o., 30 days) and arsenic exposed mice caused an increase antioxidant enzyme and decreases arsenic levels in renal tissue as compared to arsenic treated mice. No significant effect on any of these parameters was observed in mice treated with amla (500 mg/kg body weight, p.o., 30 days) alone compared to controls. A significant protective efficacy in mice simultaneously treated with arsenic and amla suggested the renal protective efficacy of amla.

Key words: Arsenic, oxidative stress, amla, mice

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How to Cite this Article

Pubmed Style

Singh MK, Katiyar DK, Yadav SS, Gupta V, Khattri S. Antioxidant role of fruit extract of Emblica officanialis (amla) against arsenic induced renal-toxicity in mice. . AAM. 2013; 2(3): 61-71.

Web Style

Singh MK, Katiyar DK, Yadav SS, Gupta V, Khattri S. Antioxidant role of fruit extract of Emblica officanialis (amla) against arsenic induced renal-toxicity in mice. . https://www.aamjournal.in/?mno=36151 [Access: June 27, 2026].

AMA (American Medical Association) Style

Singh MK, Katiyar DK, Yadav SS, Gupta V, Khattri S. Antioxidant role of fruit extract of Emblica officanialis (amla) against arsenic induced renal-toxicity in mice. . AAM. 2013; 2(3): 61-71.

Vancouver/ICMJE Style

Singh MK, Katiyar DK, Yadav SS, Gupta V, Khattri S. Antioxidant role of fruit extract of Emblica officanialis (amla) against arsenic induced renal-toxicity in mice. . AAM. (2013), [cited June 27, 2026]; 2(3): 61-71.

Harvard Style

Singh, M. K., Katiyar, . D. K., Yadav, . S. S., Gupta, . V. & Khattri, . S. (2013) Antioxidant role of fruit extract of Emblica officanialis (amla) against arsenic induced renal-toxicity in mice. . AAM, 2 (3), 61-71.

Turabian Style

Singh, Manish Kumar, Devendra Kumar Katiyar, Suraj Singh Yadav, Vineeta Gupta, and Sanjay Khattri. 2013. Antioxidant role of fruit extract of Emblica officanialis (amla) against arsenic induced renal-toxicity in mice. . Annals of Ayurvedic Medicine, 2 (3), 61-71.

Chicago Style

Singh, Manish Kumar, Devendra Kumar Katiyar, Suraj Singh Yadav, Vineeta Gupta, and Sanjay Khattri. "Antioxidant role of fruit extract of Emblica officanialis (amla) against arsenic induced renal-toxicity in mice. ." Annals of Ayurvedic Medicine 2 (2013), 61-71.

MLA (The Modern Language Association) Style

APA (American Psychological Association) Style


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