Abstract
Background: Rasa Shastra is a specialized branch of Ayurveda which evolved from 1st to 5th century in India. The branch deals with therapeutics of substances of plant, animal and mineral origin, which are moderate to severely toxic in raw form. However, there are various methodologies to transform them into non-toxic therapeutic form. A complex compound was initially prepared in mid seventies using Copper, Mercury and Sulphur as base materials that were processed with devdali (Luffa echinata Roxb.), aprajita (Clitoria ternatea L.) and fresh lemon juice. The compound was found clinically effective in treating pancreatic disorders. This study was conducted in 2015-17 with the aim of developing standard operative procedures and quality parameters along with understanding the chemical structure of the compound. Methodology: Three batches of the formulation were prepared. The process involved repeated grinding and heating of the amalgamation of the ingredients under controlled conditions. The grinding and heating specifications were monitored and documented. Samples were collected at various steps and the raw materials, in-process and finished compounds were subjected to chemical analysis at Indian Institute of Science, Bengaluru. Outcome: Standard Operative Procedure for the preparation of the stated formulation was developed. The results of the chemical analysis showed formation of new mineral peaks. The final product was devoid of any free metals. Conclusion: The study shows that the traditional methodologies described in Rasa Shastra possess potential to convert metals into mineral forms that are therapeutically effective and safe. The science needs to be further explored and developed.

Key words: Rasa Shastra; Ayurveda; Pancreatitis; Pancreatic disorders