Investigation of phytochemicals, spectral properties, anticancer, antidiabetic, and antimicrobial activities of chosen Ayurvedic remedies.

T. H. Mohamed Ahadu Shareef; Irfan Navabshan; M Mohamed Divan Masood; T. Eswara Yuvaraj

doi:10.5455/AAM.236943

2026, Vol: 15, Issue: 3

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Original Research

AAM. 2026; 15(3): 568-585

doi: 10.5455/AAM.236943

Investigation of phytochemicals, spectral properties, anticancer, antidiabetic, and antimicrobial activities of chosen Ayurvedic remedies.

T. H. Mohamed Ahadu Shareef, Irfan Navabshan, M Mohamed Divan Masood, T. Eswara Yuvaraj.

Abstract
Background: This study screened phytochemical properties, spectral characteristics, antimicrobial, antidiabetic and anticancer effects of the selected three significant Ayurvedic medicines (Kottakkal Ayurveda Triphala, Hinguvachadi Churnam and Jirakadyarishtam). Aim: This study explores anticancer properties (human colorectal carcinoma cell lines), antimicrobial properties (Bacterial and fungal strains) and In-Vitro antidiabetic efficacy of Triphala preparation. Methods: GC-MS and LC-MS analyses were conducted to identify the bioactive compounds in Triphala, Hinguvachadi Churnam, and Jirakadyarishtam, resulting in 30, 45, 8, and 15, 20, and 16 peaks that correspond to their bioactive compounds. Characterisation was carried out using FT-IR, UV–vis and ¹H-NMR spectroscopy to identify functional groups and chemical constituents. Results: The bioactive compound 8Ta found in Triphala exhibited a docking score and computed MMGBSA dG bind values against 6ULM of -10.73 and -59.52 kcal/mol, respectively. These docking scores confirmed its promising In-Vitro anticancer activity against the human colorectal carcinoma cell lines. In all three Ayurvedic extracts, a 5 (µg/ml) concentration declines the proliferation of the human colorectal carcinoma cell line by 33.42%, 28.06% and 26.79%, respectively. Conclusion: Three Ayurvedic remedies confirmed their significant antibacterial, antifungal, antidiabetic, and anticancer effects compared to standard drugs. Furthermore, In-Vivo studies are required to expand the pharmacological knowledge of these drugs for other ailments.

Key words: Ayurvedic Drug, Molecular Docking, Anticancer, Antidiabetic, Antimicrobial.

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How to Cite this Article

Pubmed Style

Shareef THMA, Navabshan I, Masood MMD, Yuvaraj TE. Investigation of phytochemicals, spectral properties, anticancer, antidiabetic, and antimicrobial activities of chosen Ayurvedic remedies.. AAM. 2026; 15(3): 568-585. doi:10.5455/AAM.236943

Web Style

Shareef THMA, Navabshan I, Masood MMD, Yuvaraj TE. Investigation of phytochemicals, spectral properties, anticancer, antidiabetic, and antimicrobial activities of chosen Ayurvedic remedies.. https://www.aamjournal.in/?mno=236943 [Access: June 29, 2026]. doi:10.5455/AAM.236943

AMA (American Medical Association) Style

Shareef THMA, Navabshan I, Masood MMD, Yuvaraj TE. Investigation of phytochemicals, spectral properties, anticancer, antidiabetic, and antimicrobial activities of chosen Ayurvedic remedies.. AAM. 2026; 15(3): 568-585. doi:10.5455/AAM.236943

Vancouver/ICMJE Style

Shareef THMA, Navabshan I, Masood MMD, Yuvaraj TE. Investigation of phytochemicals, spectral properties, anticancer, antidiabetic, and antimicrobial activities of chosen Ayurvedic remedies.. AAM. (2026), [cited June 29, 2026]; 15(3): 568-585. doi:10.5455/AAM.236943

Harvard Style

Shareef, T. H. M. A., Navabshan, . I., Masood, . M. M. D. & Yuvaraj, . T. E. (2026) Investigation of phytochemicals, spectral properties, anticancer, antidiabetic, and antimicrobial activities of chosen Ayurvedic remedies.. AAM, 15 (3), 568-585. doi:10.5455/AAM.236943

Turabian Style

Shareef, T. H. Mohamed Ahadu, Irfan Navabshan, M Mohamed Divan Masood, and T. Eswara Yuvaraj. 2026. Investigation of phytochemicals, spectral properties, anticancer, antidiabetic, and antimicrobial activities of chosen Ayurvedic remedies.. Annals of Ayurvedic Medicine, 15 (3), 568-585. doi:10.5455/AAM.236943

Chicago Style

Shareef, T. H. Mohamed Ahadu, Irfan Navabshan, M Mohamed Divan Masood, and T. Eswara Yuvaraj. "Investigation of phytochemicals, spectral properties, anticancer, antidiabetic, and antimicrobial activities of chosen Ayurvedic remedies.." Annals of Ayurvedic Medicine 15 (2026), 568-585. doi:10.5455/AAM.236943

MLA (The Modern Language Association) Style

APA (American Psychological Association) Style

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