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2026, Vol: 15, Issue: 3
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Original Research 


Hepatoprotective Activityof Holarrhena Antidysenterica Against Isoniazid and Rifampicin Induced Hepatotoxicity In Rats

Bipin Bihari Panda, Prasanta Kumar Biswal, Kirti Rout, Dibya Ranjan Sahoo.


Abstract
ABSTRACT: The present study investigates to find the hepatoprotective activity of leaves of Holarrhena antidysenterica. The extract of leaves of Holarrhena antidysenterica were screened for its hepatoprotective activity in isoniazid and rifampicin induced liver damage in Wister albino rats. The extract at dose of 300 mg/kg were administered orally once daily. Rats were treated with oral isoniazid (75mg/kg,) and co-administered with rifampicin (150 mg/kg,), daily for 15 days. Blood samples were collected from the heart at the 16th day. The degree of protection was measured by evaluating biochemical parameters such as serum glutamate Oxaloacetate transaminase (SGOT), serum glutamate pyruvate transaminase (SGPT), alkaline phosphatase (ALKP) and the level of total serum bilirubin. The livers collected were kept in formalin (10%) solution for the further histopathology study. The extract exhibited significant hepatoprotective effect and the biochemical parameters were restored towards normalization. Silymarin (25 mg/kg, po) was used as standard reference and exhibited significant hepatoprotective activity against isoniazid and rifampicin induced hepatotoxicity in rats. The protective effect of extract was also supported by histopathological study of liver tissues of animals. The results of this study strongly indicate that Holarrhena antidysenterica Linn have potent hepatoprotective action against isoniazid and rifampicin induced hepatic damage in rats.

Key words: Keywords: Holarrhena antidysenterica, Hepatoprotective, SGOT,SGPT


 
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How to Cite this Article
Pubmed Style

Panda BB, Biswal PK, Rout K, Sahoo DR. Hepatoprotective Activityof Holarrhena Antidysenterica Against Isoniazid and Rifampicin Induced Hepatotoxicity In Rats. AAM. 2026; 15(3): 560-567. doi:10.5455/AAM.282236

Web Style

Panda BB, Biswal PK, Rout K, Sahoo DR. Hepatoprotective Activityof Holarrhena Antidysenterica Against Isoniazid and Rifampicin Induced Hepatotoxicity In Rats. https://www.aamjournal.in/?mno=282236 [Access: June 29, 2026]. doi:10.5455/AAM.282236

AMA (American Medical Association) Style

Panda BB, Biswal PK, Rout K, Sahoo DR. Hepatoprotective Activityof Holarrhena Antidysenterica Against Isoniazid and Rifampicin Induced Hepatotoxicity In Rats. AAM. 2026; 15(3): 560-567. doi:10.5455/AAM.282236


Vancouver/ICMJE Style

Panda BB, Biswal PK, Rout K, Sahoo DR. Hepatoprotective Activityof Holarrhena Antidysenterica Against Isoniazid and Rifampicin Induced Hepatotoxicity In Rats. AAM. (2026), [cited June 29, 2026]; 15(3): 560-567. doi:10.5455/AAM.282236


Harvard Style

Panda, B. B., Biswal, . P. K., Rout, . K. & Sahoo, . D. R. (2026) Hepatoprotective Activityof Holarrhena Antidysenterica Against Isoniazid and Rifampicin Induced Hepatotoxicity In Rats. AAM, 15 (3), 560-567. doi:10.5455/AAM.282236


Turabian Style

Panda, Bipin Bihari, Prasanta Kumar Biswal, Kirti Rout, and Dibya Ranjan Sahoo. 2026. Hepatoprotective Activityof Holarrhena Antidysenterica Against Isoniazid and Rifampicin Induced Hepatotoxicity In Rats. Annals of Ayurvedic Medicine, 15 (3), 560-567. doi:10.5455/AAM.282236


Chicago Style

Panda, Bipin Bihari, Prasanta Kumar Biswal, Kirti Rout, and Dibya Ranjan Sahoo. "Hepatoprotective Activityof Holarrhena Antidysenterica Against Isoniazid and Rifampicin Induced Hepatotoxicity In Rats." Annals of Ayurvedic Medicine 15 (2026), 560-567. doi:10.5455/AAM.282236


MLA (The Modern Language Association) Style

Panda, Bipin Bihari, Prasanta Kumar Biswal, Kirti Rout, and Dibya Ranjan Sahoo. "Hepatoprotective Activityof Holarrhena Antidysenterica Against Isoniazid and Rifampicin Induced Hepatotoxicity In Rats." Annals of Ayurvedic Medicine 15.3 (2026), 560-567. Print. doi:10.5455/AAM.282236


APA (American Psychological Association) Style

Panda, B. B., Biswal, . P. K., Rout, . K. & Sahoo, . D. R. (2026) Hepatoprotective Activityof Holarrhena Antidysenterica Against Isoniazid and Rifampicin Induced Hepatotoxicity In Rats. Annals of Ayurvedic Medicine, 15 (3), 560-567. doi:10.5455/AAM.282236


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